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D Laurent Selected Research

vatalanib (PTK787)

9/2012Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials.
3/2012Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC).
1/2008Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate.
4/2007A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer.
6/2006Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome.
4/2005Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.

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D Laurent Research Topics

Disease

4Type 2 Diabetes Mellitus (MODY)
01/2016 - 12/2000
3Colorectal Neoplasms (Colorectal Cancer)
09/2012 - 04/2005
3Insulin Resistance
06/2009 - 08/2001
2Mitochondrial Diseases (Mitochondrial Disease)
07/2014 - 04/2013
2Neoplasms (Cancer)
03/2012 - 02/2001
2Obesity
06/2009 - 08/2001
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2016
1Alcoholic Cardiomyopathy
07/2014
1Neoplasm Metastasis (Metastasis)
09/2012
1Disease Progression
03/2012
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2012
1Sarcopenia
12/2011
1Body Weight (Weight, Body)
06/2009
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2008
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2006
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
06/2006
1Fever (Fevers)
01/2004
1Leptospirosis
01/2004
1Hyperinsulinism (Hyperinsulinemia)
06/2001
1Pneumothorax
05/2001
1Lung Neoplasms (Lung Cancer)
02/2001
1Hyperglycemia
12/2000
1Hypertrophy
03/2000
1Wounds and Injuries (Trauma)
02/2000
1Atherosclerosis
02/2000

Drug/Important Bio-Agent (IBA)

6vatalanib (PTK787)IBA
09/2012 - 04/2005
4LipidsIBA
06/2009 - 02/2000
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
09/2012 - 04/2005
3Biological ProductsIBA
06/2006 - 01/2004
2Insulin (Novolin)FDA Link
01/2016 - 06/2009
2Mitochondrial DNA (mtDNA)IBA
07/2014 - 04/2013
2Oxidants (Oxidizing Agents)IBA
04/2013 - 02/2000
2Angiogenesis InhibitorsIBA
03/2012 - 04/2007
2Glucose (Dextrose)FDA LinkGeneric
06/2009 - 12/2000
2Pioglitazone (Actos)FDA Link
06/2009 - 08/2001
2Tyrosine Kinase InhibitorsIBA
01/2008 - 04/2005
1Mitochondrial Proteins (Mitochondrial Protein)IBA
07/2014
1Ethanol (Ethyl Alcohol)IBA
07/2014
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
07/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2012
1PlatinumIBA
03/2012
1Biomarkers (Surrogate Marker)IBA
12/2011
1Fenofibrate (CiL)FDA LinkGeneric
06/2009
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
06/2009
1PPAR alphaIBA
06/2009
1PPAR gammaIBA
06/2009
1Growth Factor ReceptorsIBA
01/2008
1Imatinib Mesylate (Gleevec)FDA Link
01/2008
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2008
1Leucovorin (Folinic Acid)FDA Link
04/2007
1Fluorouracil (Carac)FDA LinkGeneric
04/2007
1Oxaliplatin (Eloxatin)FDA LinkGeneric
04/2007
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
06/2006
1GlucocorticoidsIBA
01/2005
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2005
1Transaminases (Aminotransferases)IBA
01/2004
1Nonesterified Fatty Acids (NEFA)IBA
08/2001
1Liver GlycogenIBA
06/2001
1Glycogen Synthase (Synthase I)IBA
06/2001
1FructoseIBA
06/2001
1RadonIBA
02/2001
1Metformin (Glucophage)FDA LinkGeneric
12/2000
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
03/2000
1LigandsIBA
03/2000
1fas Receptor (CD95 Antigen)IBA
03/2000
1oxidized low density lipoproteinIBA
02/2000
1Glutathione (Reduced Glutathione)IBA
02/2000

Therapy/Procedure

2Drug Therapy (Chemotherapy)
03/2012 - 04/2007
1Therapeutics
09/2012
1Communication Aids for Disabled (TDD)
03/2012
1Induction Chemotherapy
06/2006
1Vaginal Hysterectomy
05/2001